{"id":11,"date":"2026-05-25T13:17:03","date_gmt":"2026-05-25T13:17:03","guid":{"rendered":"https:\/\/pamphora.com\/?page_id=11"},"modified":"2026-05-26T15:10:17","modified_gmt":"2026-05-26T15:10:17","slug":"pamphora","status":"publish","type":"page","link":"https:\/\/pamphora.com\/","title":{"rendered":"Pamphora"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|tablet&#8221; module_class=&#8221;clinic-9-header&#8221; _builder_version=&#8221;4.17.4&#8243; _module_preset=&#8221;default&#8221; use_background_color_gradient=&#8221;on&#8221; background_color_gradient_direction=&#8221;138deg&#8221; background_color_gradient_stops=&#8221;#0470c2 41%|rgba(255,255,255,0) 100%&#8221; background_color_gradient_overlays_image=&#8221;on&#8221; background_image=&#8221;https:\/\/pamphora.com\/wp-content\/uploads\/2026\/05\/AdobeStock_1861887349_Preview.jpeg&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;163px||163px||true|false&#8221; 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max_width=&#8221;1290px&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;2_3&#8243; _builder_version=&#8221;4.17.6&#8243; _module_preset=&#8221;default&#8221; custom_css_main_element=&#8221;margin:auto;&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.17.4&#8243; _module_preset=&#8221;default&#8221; header_font=&#8221;Cinzel|700|||||||&#8221; header_text_align=&#8221;left&#8221; header_text_color=&#8221;#FFFFFF&#8221; header_font_size=&#8221;75px&#8221; header_line_height=&#8221;1.1em&#8221; max_width=&#8221;700px&#8221; custom_margin=&#8221;0px||19px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; header_font_size_tablet=&#8221;39px&#8221; header_font_size_phone=&#8221;36px&#8221; header_font_size_last_edited=&#8221;on|tablet&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h1>Move beyond PEG in nucleic acid delivery<\/h1>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.17.4&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;Open Sans||||||||&#8221; text_text_color=&#8221;#FFFFFF&#8221; text_font_size=&#8221;18px&#8221; text_line_height=&#8221;1.6em&#8221; max_width=&#8221;585px&#8221; max_width_tablet=&#8221;100%&#8221; max_width_phone=&#8221;100%&#8221; max_width_last_edited=&#8221;on|tablet&#8221; custom_margin=&#8221;0px||36px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>Our proprietary PEG-free lipid nanoparticle platform is designed to overcome the limitations of PEGylated LNPs, enabling improved efficacy, repeat dosing, and organ targeting.<\/p>\n<p>[\/et_pb_text][et_pb_button button_url=&#8221;#explore&#8221; button_text=&#8221;Explore Partnership &#038; Collaboration Opportunities&#8221; button_alignment=&#8221;left&#8221; _builder_version=&#8221;4.17.4&#8243; _module_preset=&#8221;default&#8221; custom_button=&#8221;on&#8221; button_text_size=&#8221;14px&#8221; button_text_color=&#8221;#FFFFFF&#8221; 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_builder_version=&#8221;4.18.0&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<style><!-- [et_pb_line_break_holder] -->.clinic-9-header<!-- [et_pb_line_break_holder] -->.et_contact_bottom_container {<!-- [et_pb_line_break_holder] -->    float: none;<!-- [et_pb_line_break_holder] -->    text-align: center;<!-- [et_pb_line_break_holder] -->    display: block !important;<!-- [et_pb_line_break_holder] -->}<!-- [et_pb_line_break_holder] --><\/style>\n<p>[\/et_pb_code][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|phone&#8221; _builder_version=&#8221;4.18.0&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;120px||120px||false|false&#8221; custom_padding_tablet=&#8221;120px||120px||false|false&#8221; custom_padding_phone=&#8221;90px||90px||false|false&#8221; 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vertical_offset=&#8221;25px&#8221; horizontal_offset=&#8221;138px&#8221; z_index=&#8221;-1&#8243; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.18.0&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;|||123px|false|false&#8221; custom_padding_tablet=&#8221;|||0px|false|false&#8221; custom_padding_phone=&#8221;|||0px|false|false&#8221; custom_padding_last_edited=&#8221;on|tablet&#8221; animation_style=&#8221;slide&#8221; animation_direction=&#8221;right&#8221; animation_duration=&#8221;700ms&#8221; animation_delay=&#8221;750ms&#8221; animation_speed_curve=&#8221;ease&#8221; custom_css_main_element=&#8221;margin:auto;&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.17.4&#8243; _module_preset=&#8221;default&#8221; header_3_font=&#8221;Cinzel|700||on|||||&#8221; header_3_text_align=&#8221;left&#8221; header_3_text_color=&#8221;#011954&#8243; header_3_font_size=&#8221;14px&#8221; header_3_letter_spacing=&#8221;1.8px&#8221; custom_margin=&#8221;-9px||8px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>About Pamphora<\/h3>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.17.4&#8243; _module_preset=&#8221;default&#8221; header_2_font=&#8221;Cinzel|700|||||||&#8221; header_2_text_align=&#8221;left&#8221; header_2_text_color=&#8221;#011954&#8243; header_2_font_size=&#8221;54px&#8221; header_2_line_height=&#8221;1.1em&#8221; custom_margin=&#8221;0px||15px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; header_2_font_size_tablet=&#8221;54px&#8221; header_2_font_size_phone=&#8221;30px&#8221; header_2_font_size_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Advancing Nucleic Acid Delivery<\/h2>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.17.4&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;Open Sans||||||||&#8221; text_text_color=&#8221;#3d3d3d&#8221; text_font_size=&#8221;18px&#8221; text_line_height=&#8221;1.6em&#8221; custom_margin=&#8221;0px||46px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; hover_enabled=&#8221;0&#8243; text_font_size_tablet=&#8221;18px&#8221; text_font_size_phone=&#8221;17px&#8221; text_font_size_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p>Pamphora is developing a next-generation PEG-free lipid nanoparticle (LNP) platform for nucleic acid delivery. Our technology is designed to overcome key limitations associated with current PEGylated LNP systems, including reduced efficacy during repeat dosing and unwanted immune responses.<\/p>\n<p>By enabling improved delivery performance, repeat administration, and expanded organ targeting potential, Pamphora aims to support the next wave of mRNA and nucleic acid therapeutics across a wide range of applications.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|phone&#8221; prev_background_color=&#8221;#ffffff&#8221; _builder_version=&#8221;4.18.0&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#ecf4fa&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;120px||0px||false|false&#8221; custom_padding_tablet=&#8221;120px||0px||false|false&#8221; custom_padding_phone=&#8221;90px||0px||false|false&#8221; top_divider_style=&#8221;curve&#8221; top_divider_height=&#8221;50px&#8221; bottom_divider_color=&#8221;#FFFFFF&#8221; bottom_divider_height=&#8221;276px&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.18.0&#8243; _module_preset=&#8221;default&#8221; width=&#8221;90%&#8221; max_width=&#8221;1290px&#8221; custom_margin=&#8221;0px||50px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.18.0&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.17.4&#8243; _module_preset=&#8221;default&#8221; header_3_font=&#8221;Cinzel|700||on|||||&#8221; header_3_text_align=&#8221;left&#8221; header_3_text_color=&#8221;#011954&#8243; header_3_font_size=&#8221;14px&#8221; header_3_letter_spacing=&#8221;1.8px&#8221; max_width=&#8221;645px&#8221; custom_margin=&#8221;0px||8px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>THE PROBLEM<\/h3>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.17.4&#8243; _module_preset=&#8221;default&#8221; header_2_font=&#8221;Cinzel|700|||||||&#8221; header_2_text_align=&#8221;left&#8221; header_2_text_color=&#8221;#011954&#8243; header_2_font_size=&#8221;50px&#8221; header_2_line_height=&#8221;1.1em&#8221; max_width=&#8221;645px&#8221; custom_margin=&#8221;0px||14px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; header_2_font_size_tablet=&#8221;54px&#8221; header_2_font_size_phone=&#8221;30px&#8221; header_2_font_size_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Current mRNA Delivery Systems Have Limitations<\/h2>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.17.4&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;Open Sans||||||||&#8221; text_text_color=&#8221;#3d3d3d&#8221; text_font_size=&#8221;18px&#8221; text_line_height=&#8221;1.6em&#8221; max_width=&#8221;645px&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; text_font_size_tablet=&#8221;18px&#8221; text_font_size_phone=&#8221;17px&#8221; text_font_size_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>Many nucleic acid therapies rely on PEGylated lipid nanoparticles (LNPs) for delivery. However, these systems can face major challenges during repeated dosing, including reduced efficacy, immune responses, and limited organ targeting. These limitations can impact therapeutic performance and restrict broader clinical applications.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_3,1_3,1_3&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;2&#8243; make_equal=&#8221;on&#8221; _builder_version=&#8221;4.17.4&#8243; _module_preset=&#8221;default&#8221; width=&#8221;90%&#8221; max_width=&#8221;1290px&#8221; max_width_tablet=&#8221;405px&#8221; max_width_phone=&#8221;405px&#8221; max_width_last_edited=&#8221;on|tablet&#8221; custom_margin=&#8221;0px||-90px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.17.4&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#026cbe&#8221; transform_translate_linked__hover=&#8221;off&#8221; custom_padding=&#8221;88px|41px|76px|41px|false|false&#8221; custom_padding_tablet=&#8221;88px|41px|76px|41px|false|false&#8221; 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icon_color=&#8221;#FFFFFF&#8221; _builder_version=&#8221;4.17.4&#8243; _module_preset=&#8221;default&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;][\/et_pb_icon][et_pb_text _builder_version=&#8221;4.17.4&#8243; _module_preset=&#8221;default&#8221; header_4_font=&#8221;Cabin|700|||||||&#8221; header_4_text_align=&#8221;center&#8221; header_4_text_color=&#8221;#FFFFFF&#8221; header_4_font_size=&#8221;22px&#8221; custom_margin=&#8221;0px||6px||false|false&#8221; custom_padding=&#8221;14px||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h4>Reduced Efficacy Over Time<\/h4>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.17.4&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;Nunito||||||||&#8221; text_text_color=&#8221;rgba(255,255,255,0.8)&#8221; text_font_size=&#8221;17px&#8221; text_line_height=&#8221;1.6em&#8221; text_orientation=&#8221;center&#8221; custom_margin=&#8221;0px||28px||false|false&#8221; 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global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Help Shape the Future of PEG-Free Nucleic Acid Delivery<\/h2>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.17.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.17.4&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;Open Sans||||||||&#8221; text_text_color=&#8221;#FFFFFF&#8221; text_font_size=&#8221;16px&#8221; text_line_height=&#8221;1.6em&#8221; max_width=&#8221;645px&#8221; custom_margin=&#8221;0px||0px|83px|false|false&#8221; custom_padding=&#8221;0px|0px|16px|29px|false|false&#8221; hover_enabled=&#8221;0&#8243; text_font_size_tablet=&#8221;18px&#8221; text_font_size_phone=&#8221;17px&#8221; text_font_size_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221; content_last_edited=&#8221;on|tablet&#8221; content_tablet=&#8221;<\/p>\n<p style=%22text-align: center;%22>Share your insights on current challenges in mRNA and nucleic acid delivery, including repeat dosing, PEG-associated limitations, and extrahepatic targeting.<\/p>\n<p>&#8221; 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